KPV 10mg
Anti-inflammatory companion peptide for routine consistency.
Best For
Layering into an existing wellness routine
What to Review
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About This Formula
KPV is a tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-melanocyte stimulating hormone (α-MSH). It retains the anti-inflammatory activity of its parent peptide while being significantly smaller and more stable. KPV binds to melanocortin receptors — particularly MC1R and MC3R — and inhibits the NF-κB inflammatory signaling pathway. Research has focused on its potential in inflammatory bowel conditions, gut permeability, skin inflammatory disorders, and wound healing. It is studied as a localized anti-inflammatory agent that does not produce the pigmentation effects associated with full-length α-MSH.
Key Points
- C-terminal tripeptide of α-MSH with retained anti-inflammatory activity
- Inhibits NF-κB pathway — key regulator of inflammatory gene expression
- Studied for gut permeability, IBD models, and intestinal barrier support
- Research interest in topical wound healing and skin inflammatory conditions
Administration
Subcutaneous injection or oral administration (some research uses oral or rectal routes for gut-targeted applications). Requires reconstitution with bacteriostatic water for injectable use.
Routine Notes
Often added to a recovery or companion stack where systemic inflammation management is a priority. Particularly relevant for those pairing with a high-intensity metabolic peptide that may affect GI tolerance.